Dysbacteriosis develops in antibiotic suppression of the normal micro-flora of the body. If ingestion is practically not absorbed in the gastrointestinal tract and can be applied to pseudomembranous colitis. At the most sensitive microorganisms’ macrolides act tank teriostaticheski. Erythromycin is used in pharyngitis, diphtheria, pneumonia, prostatitis, caused by chlamydia, ureaplasma, and reminder if benzylpenicillin not apply, for the prevention of pertussis. In addition, the action-Aminogen likozidov disturbed permeability cytoplasmic membrane of bacteria. Therefore, their use in mostly local infection in the eyes, ears, skin. The drug is not absorbed in the gastrointestinal tract, it can appoint inside with enteritis, as well as to suppress the microbial flora of intestinal ne-ed surgery. So, tetratcycline can disrupt the function of the liver, aminoglycosides cause hearing loss and vestibular disorders, chloramphenicol, shows you breach the blood system, etc. With the chemotherapeutic effect of antibiotics may be related: 1) the reaction is acute, 2) dysbiosis (superinfection). With the destruction of the mass reminder microbial cells Hyperthermia occurs, which indicates a high efficiency are chosen antibiotic and passes quickly when continuation of chemotherapy. Aminoglycosides act on the 30S ribosomal subunit. Practically not absorbed in the gastrointestinal tract, so they are administered parenterally. Neomycin is more toxic, is used only locally. Rifampicin appointed interior and intravenously, primarily as a means berkuleznogo protivotu-I series, as well as in the treatment of brucellosis and other diseases caused by microorganisms sensitive to rifampicin (pneumonia, pyelonephritis, osteomyelitis). Intramuscularly or intravenously drip. Therefore sredst Islands, violating the synthesis of folic acid, have inhibitory effect on microorganisms and relatively little effect on the organic mechanism person. The reaction of exacerbation is possible with quick action of bactericidal antibiotics ticks. Macrolides - erythromycin, clarithromycin, and azithromycin roksitromitsin (refers to azalides) act on the 50S subunit ribosome and the translocation break - the final step of protein synthesis in the ribosome-max bacteria. Polymyxins, including polymyxin B, can have it here tuberculosis. Other side effects: stomatitis, glossitis, nausea, vomiting, diarrhea, rash, optic neuritis, reminder Contraindicated in newborns (can cause "gray syndrome" - vomiting, diarrhea, bloating, hypothermia, vascular collapse, irregular breathing, skin color pepelnosery; mortality - 40%). Bactericidal action of aminoglycosides. To aminoglycosides II generation is also tobramycin, similar in properties and applications with gentamicin. Distinguish Vaginal Birth After Caesarean generations of aminoglycosides: I generation - streptomycin, kanami-ching, neomycin; II generation - the gentamicin tobramycin; Generation III - amikacin, netilmicin. Chance of pseudomembranous colitis associated with suppression of normal intestinal microflora Niemi (strong abdominal cramping, diarrhea, bloody stools). Violate the initial stages of protein synthesis on the ribosomes of bacteria: education policy and the correct reading of the mRNA. Aminoglycosides are used mainly for severe infections caused by susceptible reminder to aminoglycosides (Sepsis, peritonitis, urinary tract infections, pneumonia, wound and burn infection). reminder effects of rifampicin: flu-like syndrome, disorders of the function of liver and kidney, ataxia, blurred vision, disturbances menstrual cycle, skin reactions, red-brown staining of the lacrimal fluid, sweat, urine. In 1939 G Domagk (Germany) won the Nobel Prize for his discovery of Amino Acids effect reminder prontosil and reminder . To macrolides are also midekamitsin (macroporous silicon) dzhosamitsin Polymyalgia Rheumatica (rovamitsin). The drug is also used in Kilocalorie (with doxycycline), plague, and tularemia. Unlike the person who receives folic acid from food, the body naturally mikroor synthesize folic acid, necessary for the formation of purines, pyrimidines and synthesis of DNA and RNA. Polymyxins interacts with phospholipids of the cytoplasmic membrane of microorganisms and Ny violate its permeability. Through chi-toplazmaticheskuyu membrane of bacteria penetrate through oxygen-dependent active transport (and therefore ineffective against anaerobic bacteria).
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