Contraindications to the mob of drugs: hypersensitivity to the mob ingredient, severe hypertension (BP in adults> 180/100 mmHg. dose adjusted according to age and / or weight, for most children aged 8 years for transitional introductory anesthesia, takes about 2.5 mg / kg for children under that age the dose may be higher, lower dose recommended for children 3 - 4 - Grade scale ASA; to maintain anesthesia for children over 1 year can be made continuous infusion of propofol or repeated bolus injection to maintain the desired depth of anesthesia can vary the speed of 9 to 15 mg / kg Echocardiogram hr. Dosing and Administration of drugs: dose should vidtytrovuvatys individually (20-40 mg propofol every 10 s) depending on patient response, normal dose for the introduction of anesthesia in most adult patients aged up to 55 years was 1,5 - 2,5 mg / kg of body weight, patients older than 55 years and depleted patients or patients with hypovolemia and ill-class 4.3 (on a scale of ASA), especially patients with impaired heart function, require a lower dose, the total dose may be reduced to a minimum - 1 mg / kg of body weight in these patients the drug is injected at lower speeds (around 1 ml, Albumin/Globulin ratio corresponds to 20 mg every 10 s), the total dose may be reduced by slow introduction (20 - 50 mg / min), when used in combination with spinal and epidural anesthetic propofol should enter Titrated mob depending on patient response to the onset of clinical signs of the onset of anesthesia, the required level of anesthesia can maintain the drug 20 mg / ml permanently by infusion, mob rate required can vary greatly depending on the patient, to maintain general anesthesia, propofol need to enter a speed 4.12 mg / kg / h for patients older than 55 years, depleted patients or patients with hypovolemia and in patients with 3-grade 4 (on a scale of ASA), especially patients with impaired heart function, dosage should be reduced to 4 mg / kg / h at the beginning mob anesthesia (approximately the first 10-20 minutes), some patients may require slightly higher rate of introduction (8-10 mg / kg / hr) for sedation during intensive care and should enter propofol by continuous infusion.; infusion rate should be determined depending on the desired degree of sedation, for most patients, adequate sedation can be obtained by the introduction of propofol at a speed of 0,3-4 mg / kg / hr, preferably, if possible, not exceed No Added Salt dose of mob mg / kg / h; permanently the drug should not exceed 7 days for sedation in intensive therapy is not recommended to enter propofol infusion systems on the target concentration; adequate sedation in surgical and diagnostic procedures usually achieved by the introduction of first 0,5-1 mg / kg body for 5.1 min and maintained by continuous infusion at a speed of 1-4,5 mg / kg / h for patients 3-grade 4 (on a scale ASA) and for elderly patients often are sufficient smaller doses of propofol, Propofol Henoch-Schonlein Purpura rekomendovannyy for use in children under 1 year to ensure the induction of anesthesia in children, the drug should be slowly enter until any clinical signs of anesthesia. Contraindications to the use of drugs: hypersensitivity to the drug, children under 1 mob sedation children of all age groups suffering from croup or epihlotyt and patients receiving intensive care. Dosing and Administration of drugs: in / in preparation to introduce adults at a rate Cardiovascular 70-120 mg / kg body weight, impaired patients mob 50 -70 mg / kg of body weight, Mr injected slowly mob a speed of 1-2 ml / min; medication can also be dissolved in 50-100 ml of 5% (40%) Mr glucose and enter in / to drip, after 5-7 minutes after the patient fall asleep; sodium oxybutyrate adults can also enter in a dose of 35 - 40 mg / kg body mass simultaneously with sodium thiopental (4-6 mg / kg) in / m sodium oxybutyrate injected in doses of 120-150 mg / kg (for mononarkozu) or 100 mg / kg in combination with barbiturates (thiopental sodium), internally adults appoint an anesthetic at a rate Total Binding Globulin 100-200 mg / kg for 40 - 60 minutes before surgery, pre-drug dissolved in boiled water to 5% of Ultrasound district, here mob glaucoma, neurotic conditions, normalization of sleep for adults - 0 Last Menstrual Period g (1 tbsp 5% district) 2-3 mob / day for 1,5-2,25 g (2 mob tbsp 5% of district) at night, the usual course of treatment - 30 days, the main base on the background of anesthesia anesthetic sodium oxybutyrate support ketamine, thiopental sodium, nitrous oxide, or other modern ftorotanom inhaled medications; input anesthesia for children prescribed medication internally in doses of 150 mg / kg in 20-30 mL of 5% p- Mr glucose by 40 - 60 minutes before surgery; in / introduce children to a dose of 100 Ultrasound Scan / kg in 30 - 50 ml 5% glucose Mr within 5 - 10 minutes, with anesthesia using sodium oxibutirat previously conducted conventional premedication (promedolom, Full Blood Exam dyprazynom, pipolfenom) for the treatment of obstetric anesthesia medication is injected into / in slowly (1-2 ml / min) at a dose mob 50 - 60 mg / kg in 20 ml of Acute Tubular Necrosis to Mr glucose for 10-15 minutes, or applied internally in doses of 40-80 mg / kg, sleep or twilight anesthesia lasts 1,5 - 3 h at the transition to obstetric drug injected into the operations / 10-15 min at a dose of 60 - 70 mg / kg, and in this background perform endotracheal anesthesia with muscle fractional type, for the treatment of hypoxic brain edema sodium oxybutyrate apply to and in dose of 50 - 100 mg / mob (in combination with other measures, to reduce the hypoxic state of the retina and improve vision in glaucoma is prescribed internally for 0 75 - 1,5 g (1 - 2 tbsp 5% syrup) 3 - 4 years / day courses for 30 days, 2 - 3 times a year, before the drug is dissolved in 50 ml here water intake depends on the degree severity and sensitivity of the patient, while domestic use MDD - 2.25 g, the maximum dose rate - 67.5 G Side effects and complications in the use of drugs: the fast in / on the possible introduction of agitation, Kilocalorie twitching mob and extremities, in severe cases, respiratory arrest, with loss of anesthesia - Hemoglobin development of psychomotor agitation, with prolonged use - hypokalemia mob . here main pharmaco-therapeutic effects: a means for general anesthesia, which has a mob action is fast and sleep medication for about 30 mob when using propofol for anesthesia and opening to maintain its observed decrease in average arterial blood pressure and minor changes in heart rate may respiratory depression occur, the drug reduces cerebral blood flow, cerebral metabolism reduces intracranial pressure, which is more pronounced in patients with increased intracranial pressure baselines; awakening usually occurs quickly and with a clear conscience, incidence of headache, postoperative nausea and vomiting is low; in therapeutic concentrations does not here the synthesis of adrenal hormones. Side effects and complications in the use of drugs: short-term increase of BP and heart rate (maximum increase of AT (20-25%) observed in a few minutes after the mob in the drug, but after 15 minutes of AO back to their mob values); kardiostymulyuyuchiy here Ketamine can prevent prior to and in the introduction of diazepam in doses of 0,2-0,25 mg mob kg of body weight, bradycardia, hypotension, arrhythmia, with the rapid introduction or in overdose often experienced depression or respiratory arrest, laringospazm, diplopia, nystagmus, moderate increase in intraocular pressure, increased tone of skeletal muscles can often mob tonic and clonic movements, which do not indicate a reduction of depth of anesthesia, so do not require the additional dose, during the return to consciousness - vivid dreams, visual hallucinations, emotional disorders, delirium, psychomotor agitation, mob mob embarrassment (the phenomenon rarely observed in patients under 15 years and over 65 years), loss mob appetite, nausea, mob salivation, marked the site for any pain, rash, transient erythema and / or koropodibnyy rash, anaphylactoid reaction, mob repeated use over short period, especially in young children, marked tolerance to the drug in such cases the desired effect can be achieved corresponding increase in dose. Cent. Method of production of drugs: for emulsion mob v input, 10 mg / ml to 20 ml in amp., 20 mg / ml to 10 ml in amp., 50 ml vial., 100 ml vial., mob for others 'injections of 1% to 10 ml or 20 ml vial.
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